Single-Molecule and Single-Cell Manipulation Experiments

Our research focuses on understanding the interactions of biological molecules and complexes. We use atomic force microscopy to study the forces between and within single biological molecules or cells. The development of single-molecule, and single-cell techniques to studying molecular properties at the molecular level has expanded our understanding on the details of how biology and medicine function at the microscopic level. We are studying cell-cell interactions related to cancer invasion and metastasis, protein-nucleic interactions, virus assemblies, and protein-cell interactions. as well as developing new nanomanipulation techniques to study the properties of single-molecules.